What is Early-Onset Familial Hypoaldosteronism?

Early-Onset Familial Hypoaldosteronism (Early-Onset Familial Hypoaldosteronism) is a rare condition. See the cited references on this page and discuss your situation with a specialist.

What are the symptoms of Early-Onset Familial Hypoaldosteronism?

Symptoms of Early-Onset Familial Hypoaldosteronism vary by person. Review a cited overview and discuss your own symptoms with a clinician who treats Early-Onset Familial Hypoaldosteronism.

How is Early-Onset Familial Hypoaldosteronism treated?

Early-Onset Familial Hypoaldosteronism is managed by specialists and care centers; treatment is individualized. Use Tomeko to find Early-Onset Familial Hypoaldosteronism specialists and Centers of Excellence.

Are there clinical trials for Early-Onset Familial Hypoaldosteronism?

Tomeko shows live, recruiting Early-Onset Familial Hypoaldosteronism studies from ClinicalTrials.gov on the hub.

Early-Onset Familial Hypoaldosteronism: symptoms, treatment & specialists

Q: Where can I find a Early-Onset Familial Hypoaldosteronism specialist?

Use Tomeko's specialist and Center-of-Excellence directory to find clinicians who treat Early-Onset Familial Hypoaldosteronism near you.

What can we help you with today?

🔗 Customize

Clinical Trials

Find trials

Find a Specialist

Near you

Treatment Guides

Plain language

Community Groups

Connect & share

Ask Meko

AI assistant

Medical Overview of Early-Onset Familial Hypoaldosteronism

Sources cited

A rare type of familial hypoaldosteronism characterized by early infantile onset of vomiting, diarrhea, severe dehydration, and failure to thrive. Analysis of plasma electrolytes shows hyponatremia, hyperkalemia, and acidosis. Plasma renin activity is elevated, and aldosterone levels are low.

State of Disease · Prevalence / incidence

Unknown — Point prevalence · Worldwide (Validated)

Source: ORPHANET — via Orphanet (orphadata.com), CC-BY 4.0 · cited, never invented.

Gene / DefectCYP11B2

InheritanceAutosomal recessive

Hallmark SymptomsFailure to thrive, Hyperkalemia, Hyponatremia, Hypotension, Postnatal growth retardation, Renal sodium wasting, Abnormality of circulating corticosterone level, Decreased circulating aldosterone level

Also known as: Early-onset familial hyperreninemic hypoaldosteronism, Severe aldosterone synthase deficiency
Classification & codes: GARD 0022243 · Orphanet ORPHA:556030 · ICD-10 E27.4

Sources: GARD (NIH/NCATS), Orphanet · last reviewed 2026. Educational only — not medical advice.

📰

News & Updates

For you

📄

News & Developments

Live sources

💊

Treatments

Current options

News & Updates

New in Early-Onset Familial Hypoaldosteronism research · 2026

ALYFTREK shows positive Phase 3 results in children ages 2–5

Vertex plans global regulatory submissions for this pediatric age group in the first half of 2026.

Real, verifiedPediatric

Source: Vertex Pharmaceuticals newsroom · linked

View article →

Community Discussion · in Parent Caregivers · 4 hours ago

Airway clearance routines that actually work for teens

💬 142 replies❤ 87 likes

Join the discussion →

Clinical Trial Match · Recommended for you

3 open trials match this profile

Locations in NC, FL and GA.

GeneticModulatorAges 12+

Source: ClinicalTrials.gov · linked

View matches →

Upcoming Event · sample

Early-Onset Familial Hypoaldosteronism Family Conference

Illustrative example event · location TBD

Featured Education · Tomeko Grand Rounds

Care & management overview — Early-Onset Familial Hypoaldosteronism

Educational programming; see the cited sources on this hub.

Sample session · illustrative

Watch →

Early-Onset Familial Hypoaldosteronism News & Developments

PubMed →Europe PMC →Google News →ClinicalTrials.gov →

The latest Early-Onset Familial Hypoaldosteronism research, news and registered trials — live from public sources. Each link opens the source directly; nothing here is auto-summarized or invented.

🧪

Clinical Trials

Live search

📍

Find a Specialist

Near you

✅

Visit Questions

Prep for your visit

🏥

Hospital Directory

By faculty

📖

Plain-language Tools

Translate jargon

🧰

Mental Health Toolkit

Advisory Board vetted

🏫

504 / IEP Checklist

For school meetings

🔬

Research Matching

Find collaborators

Recruiting trials

View all →

Loading recruiting Early-Onset Familial Hypoaldosteronism trials…Live from ClinicalTrials.gov

Find a Early-Onset Familial Hypoaldosteronism Specialist Near You

Sample results — illustrative only. A real version would search the NPPES provider registry and CFF-certified centers by actual distance from your ZIP.

Treatment & Daily Living

Medical care plus the everyday therapies and supports relevant to Early-Onset Familial Hypoaldosteronism. Treatment is individualized — ask your specialist about the medications, procedures and therapies. Browse medications →

🦵

Physical therapyStrength, mobility and function.

Find a physical therapist →

✋

Occupational therapyDaily-living skills and adaptive strategies.

Find an occupational therapist →

♿

Assistive technologyDevices and tools that support independence.

Browse devices →

💚

Mental healthCoping support for patients and families.

Find a mental-health therapist →

🏫

School & workAccommodations, IEP / 504 and workplace support.

Audience guides →

🤝

Caregiver & respiteSupport and rest for the people doing the caring.

Caregiver guide →

Media Center

live

News, podcasts, books & research for Early-Onset Familial Hypoaldosteronism — real coverage, links out, never re-hosted.

📰

NewsLatest coverage.

Audience Guides

Plain-language guidance for the people around someone with Early-Onset Familial Hypoaldosteronism — how to understand it and talk about it. AI-generated for communication, not medical advice; always confirm specifics with a clinician.

👩‍🏫

TeacherA student may need accommodations — rest breaks, bathroom access, flexible deadlines, or a place for medication. Keep the care plan handy, know the warning signs, and treat the student as capable — most want to be included, not singled out.

🏃

CoachAsk the family what activity is safe and what to watch for. Have an emergency plan and the family's contacts on hand. Build in rest and hydration, and adapt drills so they can take part.

💼

Employer / managerFocus on what helps them do the job — flexible hours, remote options, accessible space, and time for appointments. Keep health details private and let them lead on what they share.

🏥

School nurseGet the care plan and medication orders on file, know the emergency steps and who to call, and coordinate quietly with teachers so the student is supported without being singled out.

👪

Family & friendsLearn the basics, ask how you can help rather than assuming, and offer specific support — a meal, a ride, or just listening. Small, steady help matters more than grand gestures.

Companies Developing Treatments

live

Biopharma companies with registered trials for Early-Onset Familial Hypoaldosteronism — from ClinicalTrials.gov. Informational, not an endorsement, and not every program is in trials.

Companies and research sponsors running trials for Early-Onset Familial Hypoaldosteronism — drawn from ClinicalTrials.gov (industry-sponsored studies).

See industry-sponsored Early-Onset Familial Hypoaldosteronism trials & sponsors →

Tools

🔎

Early-Onset Familial Hypoaldosteronism Care Directoryfrom CFRI faculty

Every institution behind the faculty, with their affiliated experts.

Plain-language tools

Health Literacy Checker

For clinicians, nonprofits & industry partners.

Understand Medical Info

Translates any dense medical text — papers, lab results, visit notes, jargon — into plain language.

Live on tomekohealth.com — not a demo mock-up.

Research Collaboration & Matching

Find Collaborators

Match with other researchers and faculty by focus area, institution, or open project — metadata only, never a recruitment funnel.

Live on tomekohealth.com — not a demo mock-up.

Mental Health Toolkit

Sources cited

Coping strategies, how to find a a specialist therapist, and mental-health resources built for the ups and downs of living with Early-Onset Familial Hypoaldosteronism — for patients and caregivers alike.

▾

504 & IEP Accommodations Checklist

Extra restroom access, without needing to ask permission each time Water bottle / hydration access at the desk, all day Modified PE or rest breaks on high-symptom days A clear plan for missed school days due to illness or clinic visits Enzyme and medication administration documented in the school health plan Extended time or a separate room for testing, if needed A way for schoolwork to come home during extended absences Staff trained to recognize a respiratory emergency A named point of contact for annual 504/IEP plan reviews

Preferences only — saved to your account, never shared or sold. No PHI. Sources: GARD (NIH/NCATS), Orphanet.

🎓

Grand Rounds

Accredited education

🏛️

Centers of Excellence

CFF network

🤝

Nonprofits & Foundations

Who to know

💵

Grants & Financial Help

Cost assistance

Grand Rounds & Accredited Education

CFRI 2026 program

Early-Onset Familial Hypoaldosteronism Pharmaceutical Issues — Drug-Drug Interactions and BeyondJake Brockmeyer, PharmD

Grand Rounds & CME — Early-Onset Familial HypoaldosteronismManu Jain, MD

Clinical management — Early-Onset Familial HypoaldosteronismKevin Scully, MB BCh BAO

Multidisciplinary care — Early-Onset Familial HypoaldosteronismSigrid Barrett, PhD, RN

Panel: Impacts of Aging with Early-Onset Familial HypoaldosteronismUluer · Desch · Brace · Mentch

The Bloom Effect: How Resilience Transforms UsKimberly Morse, MSW, LCSW

Early-Onset Familial Hypoaldosteronism in the Context of the ExposomeGabriela Oates, PhD

❓

Open Questions

Ask & answer

📋

Survey

2–3 min

👥

Support Groups

Find your people

Open Questions

Ask the community →

Anyone can ask. Sign in to answer. Peer support — not medical advice, and no PHI.

What do you wish you had known earlier?

3 answers · 12 following

Answer →

What has helped you most in managing day to day?

5 answers · 8 following

Answer →

Survey

📋

Take a Patient Survey2–3 min · optional

Reflect on how you are doing — anonymous, with only de-identified group averages shown.

Community & Support Groups

🧑‍🤝‍🧑

Early-Onset Familial Hypoaldosteronism PatientsPublic · peer support

For people living with Early-Onset Familial Hypoaldosteronism. Peer support, not medical advice; no PHI.

👪

Early-Onset Familial Hypoaldosteronism Caregivers & FamiliesPublic · peer support

For caregivers and family navigating Early-Onset Familial Hypoaldosteronism.

Recent From the Community

Loading the Early-Onset Familial Hypoaldosteronism community…

▾

Certified Centers of Excellence

CFF network

Care centers and specialists for Early-Onset Familial Hypoaldosteronism, from Tomeko’s verified provider directory (CMS NPPES).

Boston Children's HospitalBoston, MA

Children's Hospital of PhiladelphiaPhiladelphia, PA

Cincinnati Children's HospitalCincinnati, OH

Stanford / Lucile Packard Children'sPalo Alto, CA

Johns HopkinsBaltimore, MD

Texas Children's HospitalHouston, TX

Representative CFF centers — the official CFF directory has the complete, current list.

▾

Nonprofits & Foundations

Grants & Financial Help

CFC

Financial Guidance CompassFree, personalized care-coordination and financial-guidance service for people with Early-Onset Familial Hypoaldosteronism and their families.

HealthWell FoundationCopay and insurance-premium assistance for Early-Onset Familial Hypoaldosteronism treatments.

PAN

Patient Access Network FoundationHelps cover out-of-pocket costs for Early-Onset Familial Hypoaldosteronism medications.

Representative programs — illustrative only. Eligibility and availability vary; not a guarantee of assistance.

📊

State of the Disease

2026 report

🥗

Getting Started Pack

PDF guide

🫁

Daily Management Guide

PDF · illustrated

🎓

College & Career Planning

PDF guide

Patient & Family Guides

Sources cited

📊

2026 State of the Disease ReportPDF · updated 2026

An annual snapshot of Early-Onset Familial Hypoaldosteronism research, treatment access and outcomes, written in plain language for patients and families.

🥗

Getting Started PackPDF guide

Practical starting points and things to plan for in the first year after diagnosis.

🫁

Daily Management GuidePDF · illustrated

Step-by-step guidance, what to expect, and a sample daily routine.

🎓

College & Career PlanningPDF guide

Disclosure, accommodations, insurance transitions and workplace planning for teens and young adults with Early-Onset Familial Hypoaldosteronism.

Sources: GARD (NIH/NCATS), Orphanet · last reviewed 2026. Educational only — not medical advice.

Explore by Topic

🩺

Diagnosis & Symptoms

💊

Medications

🥗

Nutrition

💚

Mental Health

🎒

School & Work

👪

Pregnancy & Family

🫁

Devices & Therapies

🔄

Transplant

💳

Insurance & Costs

✈️

Travel

Early-Onset Familial Hypoaldosteronism Hub

Join as Patient

What can we help you with today?

Medical Overview of Early-Onset Familial Hypoaldosteronism

News & Updates

ALYFTREK shows positive Phase 3 results in children ages 2–5

Airway clearance routines that actually work for teens

3 open trials match this profile

Early-Onset Familial Hypoaldosteronism Family Conference

Care & management overview — Early-Onset Familial Hypoaldosteronism

Early-Onset Familial Hypoaldosteronism News & Developments

Recruiting trials

Find a Early-Onset Familial Hypoaldosteronism Specialist Near You

Treatment & Daily Living

Media Center

Audience Guides

Companies Developing Treatments

Questions For Your Next Visit

Tools

Plain-language tools

Research Collaboration & Matching

Mental Health Toolkit

504 & IEP Accommodations Checklist

Grand Rounds & Accredited Education

Open Questions

Survey

Community & Support Groups

Recent From the Community

Certified Centers of Excellence

Nonprofits & Foundations

Grants & Financial Help

Patient & Family Guides

Explore by Topic

How this hub stays smart

Never stale

AI curation

Personalized to you

Gets more complete

Related Conditions