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π CustomizeMedical Overview of Acrokeratosis Verruciformis Of Hopf
Sources citedA rare, genetic, acrokeratoderma disease characterized by multiple, symmetrical, asymptomatic, skin-colored (rarely, brownish), flat-topped, wart-like papules located on the dorsal aspects of the hands and feet (occasionally found on other parts of the body, such as knees, elbows and forearms), typically associated with palmoplantar punctate keratosis and variable nail involvement (including leukonychia, thickening, ridging, longitudinal striations and splitting). Histology reveals undulating hyperkeratosis, papillomatosis, hypergranulosis, and acanthosis, creating a characteristic 'church spire' appearance, with no acantholysis nor dyskeratosis associated.
Classification & codes: GARD 0016707 · Orphanet ORPHA:79151 · OMIM 101900 · ICD-10 Q82.8
Sources: GARD (NIH/NCATS), Orphanet Β· last reviewed 2026. Educational only β not medical advice.
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ALYFTREK shows positive Phase 3 results in children ages 2β5
Vertex plans global regulatory submissions for this pediatric age group in the first half of 2026.
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3 open trials match this profile
Locations in NC, FL and GA.
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Care & management overview — Acrokeratosis Verruciformis Of Hopf
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Disclosure, accommodations, insurance transitions and workplace planning for teens and young adults with Acrokeratosis Verruciformis Of Hopf.
Sources: GARD (NIH/NCATS), Orphanet Β· last reviewed 2026. Educational only β not medical advice.